As we age, self-renewing capacities of our body naturally decline. This is because stem cell reserves of our body gradually deplete and the ability of stem cells to multiply and replace aging cells with new ones diminishes. Stressful lifestyle, malnutrition, bad habits and poor environment accelerate our body decline. Is there a chance to revert or at least slow down this process?
We offer novel anti-aging therapy using a natural, holistic approach. Our fetal stem cell programs are aimed at both the prevention of premature aging and age-related diseases, and the maintenance of youthfulness.
When introduced into a body that is aging, fetal stem cells expand stem cell reserves and trigger self-renewal processes in all the body’s organs and tissues. They also stimulate the body’s own dormant stem cells, which improves the functioning of the internal organs, boosts the immune system, and increases energy levels. The effects observed in our patients have shown genuine rejuvenation from inside!
higher energy level, exercise power and capacity to work;
firmer and tighter skin, improved hair structure and growth;
improved mental capacity, quicker thinking, better memory;
subsiding of muscular, joint and back pain, and headaches;
normalized functioning of internal organs;
stabilized metabolism, hormone levels and blood pressure;
better sleep and the elimination of chronic fatigue;
improved libido and sexual functions.
The advantages of our treatment are:
lack of side effects;
no chemicals involved;
minimally invasive procedure (intravenous infusions and subcutaneous injections);
no rejection risk;
no cancer risk;
"Our health is only as good as our immune system"
Consider three questions:
Is aging a chronic disease process?
Does that disease process have a common cause?
If so, is there a common remedy?
Now consider the facts:
Adult stem cells repair injured and diseased tissues and constantly replace worn-out normal tissues. However, as we age, there is a chronic decline in self-repair, starting from when we are quite young. In other words, aging is the result of a steady progressive decline in stem cell function.
There is broad consensus that there exists a wide range of diseases associated with aging, particularly cancer, degenerative, auto-immune, neurological and cognitive diseases. The corollary question, therefore, is this, "Is there a common thread to all these age-related diseases?"
We are aware that one of the common threads of aging is inflammation which seems to be at the root of many of the afflictions as we age. Inflammation rears its ugly head in many different fashions by affecting many different pathways in the body. These pathways control the fate of certain genes which can either be turned on or off, depending on the stimulus. These same genes can control our destiny. They can encourage many diseases or can prevent many diseases.
If we look more closely at aging we see certain trends leading to the point where Dr. Ron Dipinho, from Harvard University, has proposed the unified theory of aging. He believes that telomere damage is a major culprit and common cause of aging.
Telomeres can be simply described as tails attached to cells that represent one's DNA.
We know that telomere length steadily shortens every time the cells divide, until they eventually become no longer viable and the cells die. This gives rise to two issues. One is death itself. The other is declining quality of life the shorter the telomeres become.
Short telomeres ultimately affect the mitochondria causing them to lose effectiveness and cause the “death spiral of the cell”. The mitochondria produce free radicals which wreak havoc on the body on many different levels. Consider them like terrorists in the body unleashing damage on multiple levels. The cell is programmed such that, when its telomeres reach a certain critical level, the P-53 gene becomes active and it leads to cell death. If the P-53 gene does not eliminate the aged cell, many bad things begin to happen. A method of helping the P-53 gene is to use senolytic agents in the body. These are compounds which essentially kill senescent cells, cells that should have died but instead remain alive and secrete many inflammatory growth factors.
There is a great deal of ongoing research into the question of how to turn on the P-53 gene. At one time is was thought that too much P-53 is just as bad as too little. But the good news is that the body has some safeguards so that excess p-53 does not seem to be a problem since the body will slow down the system. It is felt that the senescent cells are a major contributor to aging since they secrete many inflammatory growth factors which wreak havoc on many different levels.
Typically, our health is only as good as our immune system. This is a very profound concept.
We know that, as telomere length shortens, our immune system declines. Plainly, if we could stem the decline in telomere length, we could not only extend our lives but live more healthily in the process.
Clinical studies done in 2016 utilizing certain autologous V-cells have been able, not only to preserve but to increase telomere length for at least six months following treatment. On older mice, their hair went from patchy grey to black and skin elasticity increased, amongst myriad other measurements taken where results were correlated with telomere length of peripheral blood leukocytes, white blood cells that form a very important part of the body's immune system. V-cells seem to turn on telomerase in other cells. Telomerase is an enzyme that can restore the ends of the DNA, thereby enabling these cells to go back in age.
Many will remember Dolly, the first cloned sheep. Few will know that Dolly died of old age at a young age. That is because the telomere length of her cells started out with the reduced length of the cells that were cloned. If the cloned animal were to be further cloned, then that life expectancy will be shorter still. The only cells that retain telomere length throughout our lives are reproductive cells which is why naturally conceived babies are born with full-length telomeres regardless of the age of their parents.
There are very few if any medications, supplements, or treatments that can actually lengthen telomeres. The very best may slow down telomere shortening by perhaps 16% but not reverse it. By contrast, V-cell procedures have been shown to reverse it!!
The following diagram represents the essence of aging, showing the stem cell aging pathways. How stem cells age, determines how the body ages. Unlike many anti-aging facilities, we are directly addressing these pathways.
Advanced Cellular Repair Division
Taking anti-aging to the next level is our advanced cellular repair division.
In our clinic, we do not use hormones etc. to try to slow down the clock of aging. Certainly, hormone therapy has its place, but we feel that this type of treatment is unlikely to be a game changer in respect of life extension. Hence, we leave such treatments to other clinics [and, of course, are happy to work with them].
For our part, we are attacking aging on a cellular-molecular biology basis. When we stimulate these pathways in the proper manner, their effects can be profound. Let us take a closer look at some of these pathways and examine how we are addressing them.
The first pathway to address is the sirt 1,3, and 6. This represents the sirtuin genes. These are generally regarded as one of the most important anti-aging pathways. These genes have a dramatic influence on the mitochondria and their health. The mitochondria produce ATP which is the fuel upon which most cell function relies. The healthier the mitochondria are, the healthier we are. As is the usual story, as we age the number and function of the mitochondria diminishes.
The sirtuin genes are influenced by a number of factors. One factor that turns them on is starvation. Starvation is scientifically proven to slow down the clock of aging. Another commonly known factor that influences the sirtuin genes is resveratrol which comes from red wine. A better alternative to resveratrol is pterostilbene. Multiple studies have demonstrated that both resveratrol and pterostilbene have preventative and therapeutic benefits on the mitochondria. However, we are now aware of a much more important compound that has monumental influence on the sirtuin gene family. This compound is called NAD. NAD stands for nicotinamide adeine dinucleotide. Actually, the supplement that is taken is called nicotinamide riboside. This gets converted to NAD.
Earlier in 2018 there was an article in time magazine touting the importance of NAD as a source of anti-aging. It is extremely important to take NAD on a daily basis. However, as we age we can ingest NAD supplements, but we have difficulty delivering NAD to the cell. The reason for this is that as we age we lack a certain enzyme which dramatically facilitates the delivery of NAD to the cell. This problem can be overcome through our advanced cellular repair division.
One of the scientists affiliated with our clinic, Dr. J Serrintino, has developed an enzyme which will increase delivery of the NAD to the cells. We have investigated this further and found that on its own, nicotinamide riboside (NR) does not promote longevity or cell health. In most organisms it is the kinase precursors (nicotinamide riboside kinase 1 & 2 NRK) that signal conversion of supplemental NR to NAD. We now have the kinase enzyme which we will deliver via a patch. This will allow dramatically increased amounts of NAD delivered to the cells. This is revolutionary and is one of the backbones of our anti-aging protocols. Indeed, it forms a central component of our advanced cellular repair division. There are no other facilities in the world that have this technology other than Dr. Purita’s other clinic located in Boca Raton, Florida.
Please read the blog on NAD which will further elucidate this subject.
Another aspect subject to scrutiny by our advanced cellular repair division concerns a gene called p-53. In a nutshell the p-53 gene is responsible for flagging down what are called senescent cells and causing them to die. A senescent cell is one which should have died but it continues to survive. Unfortunately, its continued survival causes havoc in the body since it secretes many inflammatory growth factors that cause a variety of problems including cancer, diabetes, and a host of diseases of aging.
We now have a patch available to deliver p-53 to the body which will flag and kill these senescent cells while at the same time making other cells healthier by repairing their DNA. Again, this treatment is only available in Dr. Purita's two clinics. For further information please read the blog on p-53.
As time goes on, with the guidance of Dr. Serrintino, we will be attacking the rest of the aging pathways. This will be accomplished by a combination of supplements, enzymes, and growth factors. Amongst other applications, we shall utilize these techniques on a local basis to enhance our stem cell procedures, including the treatment of joints.
So, where do does this information take us? Our view is this:
There is no substitute for exercise and a healthy diet, so keep on doing that.
Get periodic V-Cell treatments [periodic infusions of autologous V-cells plus growth factors and cytokines]. Recommended periodicity may vary, depending on one's age and other factors. More details on V-cell treatments are set out on the V-Cell page.
Who Can Benefit?
Many people at different stages in life can benefit.
Seniors can help reverse ageing diseases and live a healthier life, often with less pain and loss of faculty.
Senior executives can extend their useful working lives with better health and mental function.
Young executives, starting earlier while their cells' telomere lengths are long, can expect significantly to extend their health, mental efficiency and possibly youthfulness.
To learn more or to determine which treatment is best suited to your needs, please contact us.
Overview of VSELs
The adult pluripotent stem cell treatment we offer uses VSEL stem cells, [Very Small Embryonic Like Stem Cells], also referred to as V-Cells. They are also called peripheral blood stem cells, blastomeres or stembios cells. Formed in bone marrow, they are approximately 1/3rd the size of other adult stem cells and are non-tumorigenic. These cells measure between 2-4 microns compared to erythrocytes at about 7 microns and other stem cells that are over 10 microns. In fact, they are so small that they have the capacity to reach the parts that other cells cannot reach, including crossing the blood-brain barrier. They normally circulate in peripheral blood through our body in an inactive form and activation only occurs when our body faces extreme stress such as low oxygen, low body temperature or significant injuries. They have also been described as primordial adult stem cells that in some ways are close to being omnipotent.
Our procedure is to draw blood and then separate the VSEL stem cells from other cells using state of the art cell processing technology. The cells are then activated using certain proprietary means including the use of light and temperature. Finally, we combine these adult pluripotent stem cells (APSCs) with powerful growth factors harvested from your own platelet cells from the same blood sample.
The active APSCs and growth factors can now be returned to the body through an intravenous injection (IV) or by injection to a specific site. Once in the blood stream, the VSELs will go to work, seeking out areas of injury, inflammation and degeneration to begin the repair and regeneration process.
This procedure has helped with inflammation and autoimmune diseases such as Rheumatoid Arthritis and Ankylosing Spondylitis to name just two. It has caused a significant reversal in Osteoporosis (which can be considered an autoimmune disease) in less than a year of treatment. Improved bone density without the deleterious side effects of most traditional treatments is a very significant issue. The procedure also works quite well for most musculoskeletal conditions, particularly joint repair.
Another very interesting and important aspect about these cells is that they trigger the secretion of Telomerase, the enzyme that restores the DNA telomere ends.
Telomere degradation is a relentless process linked to aging and its associated diseases. Your telomeres were in better condition this morning than when you will go to bed tonight. This is one of the reasons why it is recommended to save babies’ cord blood. Furthermore, it is even recommended that adults may want to consider storing their stem cells in a bank to have a supply of cells with a reasonable telomere length. In some ways this is like an insurance plan.
Someday, those same cells may be used to correct a disease process that has developed. They may be used to save your life. Typically, these cells would need to be expanded by culturing them. After the culturing process they could potentially be utilized in disease treatment. This procedure would need to be done outside the US under current regulations.
Short telomeres are associated with many different diseases ranging from cancer, osteoarthritis, diabetes, and many neurological conditions including Alzheimer’s Disease, one of the scourges of modern society. The diagram below shows the difference in size between an embryonic cell and adult cell as far as the DNA and its telomere is concerned. Whilst embryonic cells have much higher regenerative capacity, they have numerous pitfalls which currently limit their use in a regenerative capacity. Furthermore, there are ethical issues associated with them. This is why the earliest recommended material to be banked is cord blood.
Trials have shown that V-Cells properly extracted, concentrated, activated and enriched with the correct growth factors have yielded cells with increased telomere length, measured on white blood cell [WBC] leukocytes for up to six months after treatment. This is a repeatable procedure. It is important to note that our procedure of V-Cell stimulation and activation is a propriety procedure, including our own unique growth factor formulations.
In summary, VSEL/V-Cells are used principally for tissue regeneration and anti-aging applications and are taking on increasing importance in our armamentarium of cells.
Although our unique process is done over three days, including preparation, very little time is required from the patient.
To determine which treatment is best suited to your needs, please contact us.
-Info taken from a clinic in the Cayman Islands.